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We extended this study and found that GSC-derived pericytes contribute to the resistance to the current anti-angiogenic therapy that targets endothelial cells, indicating that therapeutic targeting of GSC-derived pericytes may improve the anti-angiogenic therapy.
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Interestingly, loss of the receptors alone was sufficient to inhibit BTSC proliferation in vitro. Highly specific inhibitors of Eg5 are available and several have moved to phase I and II clinical trials in patients with solid malignancies.
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